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Yamaji S, Hozumi A, Matsunobu S, Sasakura Y
Orchestration of the distinct morphogenetic movements in different tissues drives tail regression during ascidian metamorphosis
Developmental Biology (2020) 465: 66-78

Hozumi A, Matsunobu S, Mita K, Treen N, Sugihara T, Horie T, Sakuma T, Yamamoto T, Shiraishi A, Hamada M, Satoh N, Sakurai K, Satake H, Sasakura Y
GABA-induced GnRH release triggers chordate metamorphosis
Current Biology (2020) 30:1555-1561


Tajima Y, Hozumi A, Yoshida K, Treen N, Sakuma T, Yamamoto T, Sasakura Y.
Hox13 is essential for formation of a sensory organ at the terminal end of the sperm duct in Ciona.
Developmental Biology (2020) 458: 120-131

Osugi T, Sasakura Y, Satake H.
The ventral peptidergic system of the adult ascidian Ciona robusta (Ciona intestinalis Type A) insights from a transgenic animal model.
Scientific Reports (2020) 10: 1892

Bostwick M, Smith EL, Borba C, Newman-Smith E, Guleria I, Kourakis MJ, Smith WC.
Antagonistic inhibitory circuits integrate visual and gravitactic behaviours.
Current Biology (2020) 30: 1-10


Sasakura Y.
Cellulose production and the evolution of the sessile lifestyle in ascidians.
Sessile Organisms 35: 21-29

Sasakura Y.
Germline transgenesis in Ciona.
Adv Exp Med Biol (2018) 1029: 109-119

Sasakura Y.
The enhancer trap in Ciona.
Adv Exp Med Biol (2018) 1029: 121-129

Satoh T, Iitsuka T, Shiraishi A, Hozumi A, Satake H, Sasakura Y.
piRNA-like small RNAs are responsible for the maternal-specific knockdown in the ascidian Ciona intestinalis Type A.
Sci Rep (2018) 8: 5869

Horie T, Horie R, Chen K, Cao C, Nakagawa M, Kusakabe TG, Satoh N, Sasakura Y, Levine M.
Regulatory cocktail for dopaminergic neurons in a protovertebrate identified by whole-embryo single-cell transcriptomics.
Genes Dev (2018) 32: 1297-1302

Horie R, Hazbun A, Chen K, Cao C, Levine M, Horie T.
Shared evolutionary origin of vertebrate neural crest and cranial placodes.
Nature (2018) 560: 228-232


Sasakura Y, Hozumi A.
Formation of adult organs through metamorphosis in ascidians.
Wiley Interdiscip Rev Biol (2017) 7

Osugi T, Sasakura Y, Satake H.
The nervous system of the adult ascidian Ciona intestinalis Type A (Ciona robusta): Insights from transgenic animal models.
PLOS one (2017) 12: e0180227.

Sasakura Y, Yoshida K, Treen N.
Genome Editing of the Ascidian Ciona intestinalis with TALE Nuclease.
Methods Mol Biol (2017) 1630: 235-245.

Yoshida K, Nakahata A, Treen N, Sakuma T, Yamamoto T, Sasakura Y.
Hox-mediated endodermal identity patterns pharyngeal muscle formation in the chordate pharynx.
Development (2017) 144: 1629-1634.

Yoshida K, Hozumi A, Treen N, Sakuma T, Yamamoto T, Shirae-Kurabayashi M, Sasakura Y.
Germ cell regeneration-mediated, enhanced mutagenesis in the ascidian Ciona intestinalis reveals flexible germ cell formation from different somatic cells.
Dev Biol (2017) 423:111-125.


Sasakura Y, Ogura Y, Treen N, Yokomori R, Park SJ, Nakai K, Saiga H, Sakuma T, Yamamoto T, Fujiwara S, Yoshida K.
Transcriptional regulation of a horizontally transferred gene from bacterium to chordate.
Proc Biol Sci (2016) 283: pii 20161712.

Ogura Y, Sasakura Y.
Developmental Control of Cell-Cycle Compensation Provides a Switch for Patterned Mitosis at the Onset of Chordate Neurulation.
Dev Cell (2016) 37: 148-161.


Hozumi A, Horie T, Sasakura Y.
Neuronal map reveals the highly regionalized pattern of the juvenile central nervous system of the ascidian Ciona intestinalis.
Dev Dyn (2015) 244: 1375-1393.

Kawai N, Ogura Y, Ikuta T, Saiga H, Hamada M, Sakuma T, Yamamoto T, Satoh N, Sasakura Y.
Hox10-regulated endodermal cell migration is essential for development of the ascidian intestine.
Dev Biol (2015) 403:43-56.

Karaiskou A, Swalla BJ, Sasakura Y, Chambon JP.
Metamorphosis in solitary ascidians.
Genesis (2015) 53:34-47.

Stolfi A, Sasakura Y, Chalopin D, Satou Y, Christiaen L, Dantec C, Endo T, Naville M, Nishida H, Swalla BJ, Volff JN, Voskoboynik A, Dauga D, Lemaire P.
Guidelines for the nomenclature of genetic elements in tunicate genomes.
Genesis (2015) 53:1-14.

Brozovic M, Martin C, Dantec C, Dauga D, Mendez M, Simion P, Percher M, Laporte B, Scornavacca C, Di Gregorio A, Fujiwara S, Gineste M, Lowe EK, Piette J, Racioppi C, Ristoratore F, Sasakura Y, Takatori N, Brown TC, Delsuc F, Douzery E, Gissi C, McDougall A, Nishida H, Sawada H, Swalla BJ, Yasuo H, Lemaire P.
ANISEED 2015: a digital framework for the comparative developmental biology of ascidians.
Nucleic Acids Res (2016) 44: D808-818.


Yokoyama TD, Hotta K, Oka K.
Comprehensive morphological analysis of individual peripheral neuron dendritic arbors in ascidian larvae using the photoconvertible protein Kaede.
Dev Dyn (2014) 243:1362-1373.

Yoshida K, Treen N, Hozumi A, Sakuma T, Yamamoto T, Sasakura Y.
Germ cell mutations of the ascidian Ciona intestinalis with TALE nucleases.
Genesis (2014) 52:431-439.

Iitsuka T, Mita K, Hozumi A, Hamada M, Satoh N, Sasakura Y.
Transposon-mediated targeted and specific knockdown of maternally expressed transcripts in the ascidian Ciona intestinalis.
Sci Rep (2014) 4:5050.

Yasunori Sasakura
Germline transformation in the ascidian Ciona intestinalis.
Sexual reproduction in animals and plants (eds H. Sawada, N. Inoue, M.Iwano). Springer 2014

Nicholas Treen, 吉田慶太, 佐々木陽香, 笹倉靖徳
実験医学別冊 今すぐ始めるゲノム編集(山本卓編)pp161-168, 2014 Mar.

Sasaki H, Yoshida K, Hozumi A, Sasakura Y
CRISPR/Cas9-mediated gene knockout in the ascidian Ciona intestinalis.
Dev Growth Differ (2014) 56:499-510.

Satou Y, Hirayama K, Mita K, Fujie M, Chiba S, Yoshida R, Endo T, Sasakura Y, Inaba K, Satoh N
Sustained heterozygosity acros a self-incompatibility locus in an inbred ascidian.
Mol Biol Evol (2014) msu268.

Kamiya C, Ohta N, Ogura Y, Yoshida K, Horie T, Kusakabe TG, Satake H, Sasakura Y.
Nonreproductive role of gonadotropin-releasing hormone in the control of ascidian metamorphosis.
Dev Dyn (2014) 243:1524-1535.

Treen N, Yoshida K, Sakuma T, Sasaki H, Kawai N, Yamamoto T, Sasakura Y.
Tissue-specific and ubiquitous gene knockouts by TALEN electroporation provide new approaches to investigating gene function in Ciona.
Development (2014) 141:481-487.


Suzuki MM, Yoshinar A, Obara M, Takuno S, Shigenobu S, Sasakura Y, Kerr ARW, Webb S, Bird A, Nakayama A
Identical sets of methylated and nonmethylated genes in Ciona intestinalis sperm and muscle cells.
Epigenetics Chromatin (2013) 6:38.

Nakazawa K, Yamazawa T, Moriyama Y, Ogura Y, Kawai N, Sasakura Y, Saiga H.
Formation of the digestive tract in Ciona intestinalis includes two distinct morphogenic processes between its anterior and posterior parts.
Dev. Dyn. (2013) 242:1172-1183.

Ogura Y, Sasakura Y.
Ascidians as excellent models for studying cellular events in the chordate body plan.
Biol Bull (2013) 224:227-236.

Sakuma T, Hosoi S, Woltjen K, Suzuki K, Kashiwagi K, Wada H, Ochiai H, Miyamoto T, Kawai N, Sasakura Y, Matsuura S, Okada Y, Kawahara A, Hayashi S, Yamamoto T.
Efficient TALEN construction and evaluation methods for human cell and animal applications.
Genes Cells (2013) 18:315-326.

Hozumi A, Yoshida R, Horie T, Sakuma T, Yamamoto T, Sasakura Y.
Enhancer activity sensitive to the orientation of the gene it regulates in the chordate genome.
Dev. Biol. (2013) 375:79-91.

Hozumi A, Mita K, Miskey C, Mates L, Izsvak Z, Ivics Z, Satake H, Sasakura Y.
Germline transgenesis of the chordate Ciona intestinalis with hyperactive variants of sleeping beauty transposable element.
Dev. Dyn. (2013) 242:30-43.


Mita K, Kawai N, Rueckert S, Sasakura Y.
Large-scale infection of the ascidian Ciona intestinalis by the gregarine Lankesteria ascidiae in an inland culture system.
Dis Aquat Organ. (2012) 101:185-195.

Nishitsuji K, Horie T, Ichinose A, Sasakura Y, Yasuo H, Kusakabe TG.
Cell lineage and cis-regulation for a unique GABAergic/glycinergic neuron type in the larval nerve cord of the ascidian Ciona intestinalis.
Dev Growth Differ. (2012) 54:177-186.

Sasakura Y, Mita K, Ogura Y, Horie T.
Ascidians as excellent chordate models for studying the development of the nervous system during embryogenesis and metamorphosis.
Dev Growth Differ. (2012) 54:420-437.

Sasakura Y, Kanda M, Ikeda T, Horie T, Kawai N, Ogura Y, Yoshida R, Hozumi A, Satoh N, Fujiwara S.
Retinoic acid-driven Hox1 is required in the epidermis for forming the otic/atrial placodes during ascidian metamorphosis.
Development. (2012) 139:2156-2160.

Kawai N, Ochiai H, Sakuma T, Yamada L, Sawada H, Yamamoto T, Sasakura Y.
Efficient targeted mutagenesis of the chordate Ciona intestinalis genome with zinc-finger nucleases.
Dev Growth Differ. (2012) 54(5):535-545.

Razy-Krajka F, Brown E, Horie T, Callebert J, Sasakura Y, Joly JS, Kusakabe T, Vernier P.
Monoaminergic modulation of photoreception in ascidian: Evidence for a proto-hypothalamo-retinal territory.
BMC Biol. (2012) 10:45.

Yoshida R, Sasakura Y.
Establishment of Enhancer Detection Lines Expressing GFP in the Gut of the Ascidian Ciona intestinalis.
Zoolog. Sci. (2012) 29: 11-20.


Yoshiyama-Yanagawa T, Enya S, Shimada-Niwa Y, Yaguchi S, Haramoto Y, Matsuya T, Shiomi K, Sasakura Y, Takahashi S, Asashima M, Kataoka H, Niwa R.
The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol metabolizing enzyme.
J Biol Chem. (2011) 286:25756-25762.

Hamada M, Shimozono N, Ohta N, Satou Y, Horie T, Kawada T, Satake H, Sasakura Y, Satoh N.
Expression of neuropeptide- and hormone-encoding genes in the Ciona intestinalis larval brain.
Dev Biol. (2011) 352:202-214.

Ogura Y, Sakaue-Sawano A, Nakagawa M, Satoh N, Miyawaki A, Sasakura Y.
Coordination of mitosis and morphogenesis: role of a prolonged G2 phase during chordate neurulation.
Development (2011) 138:577-587.

Horie T, Shinki R, Ogura Y, Kusakabe TG, Satoh N, Sasakura Y.
Ependymal cells of chordate larvae are stem-like cells that form the adult nervous system.
Nature (2011) 469:525-528.

Endo T, Ueno K, Yonezawa K, Mineta K, Hotta K, Satou Y, Yamada L, Ogasawara M, Takahashi H, Nakajima A, Nakachi M, Nomura M, Yaguchi J, Sasakura Y, Yamasaki C, Sera M, Yoshizawa AC, Imanishi T, Taniguchi H, Inaba K.
CIPRO 2.5: Ciona intestinalis protein database, a unique integrated repository of large-scale omics data, bioinformatic analyses and curated annotation, with user rating and reviewing functionality.
Nucleic Acids Res. (2011) 39(Database issue):D807-814.


Shimozono N, Ohta N, Satoh N, Hamada M.
Differential regional expression of genes in the developing brain of Ciona intestinalis embryos.
Zoolog. Sci. 27, 103-109.

Ikuta T, Satoh N, Saiga H.
Limited functions of Hox genes in the larval development of the ascidian Ciona intestinalis.
Development 137, 1505-1513.

Ohta N, Horie T, Satoh N, Sasakura Y.
Transposon-Mediated Enhancer Detection Reveals the Location, Morphology and Development of the Cupular Organs, which are Putative Hydrodynamic Sensors, in the Ascidian Ciona intestinalis.
Zoolog Sci. (2010) 27:842-850.

Terakubo HQ, Nakajima Y, Sasakura Y, Horie T, Konno A, Takahashi H, Inaba K, Hotta K, Oka K.
Network structure of projections extending from peripheral neurons in the tunic of ascidian larva.
Dev Dyn. (2010) 239:2278-2287.

Hozumi A, Kawai N, Yoshida R, Ogura Y, Ohta N, Satake H, Satoh N, Sasakura Y.
Efficient transposition of a single Minos transposon copy in the genome of the ascidian Ciona intestinalis with a transgenic line expressing transposase in eggs.
Dev Dyn. (2010) 239:1076-1088.

Horie T, Nakagawa M, Sasakura Y, Kusakabe TG, Tsuda M.
Simple Motor System of the Ascidian Larva: Neuronal Complex Comprising Putative Cholinergic and GABAergic/Glycinergic Neurons.
Zoolog Sci. (2010) 27:181-190.

Auger H, Sasakura Y, Joly JS, Jeffery WR.
Regeneration of oral siphon pigment organs in the ascidian Ciona intestinalis.
Dev Biol. (2010) 339:374-389.

Sasakura Y, Suzuki MM, Hozumi A, Inaba K, Satoh N.
Maternal factor-mediated epigenetic gene silencing in the ascidian Ciona intestinalis.
Mol Genet Genomics. (2010) 283 : 99-110.


Yasunori Sasakura, Kazuo Inaba, Nori Satoh, Mariko Kondo, Koji Akasaka.
Ciona intestinalis and Oxycomanthus japonicus, representatives of marine invertebrates.
Experimental Animals (2009) 58, 459-469.

Horie T, Nakagawa M, Sasakura Y, Kusakabe TG.
Cell type and function of neurons in the ascidian nervous system.
Development Growth & Differentiation 2009 51;207-220.

Dahlberg C, Auger H, Dupont S, Sasakura Y, Thorndyke M, Joly JS.
Refining the Ciona intestinalis model of central nervous system regeneration.
PLoS ONE. (2009);4:e4458.

Nakayama-Ishimura A, Chambon JP, Horie T, Satoh N, Sasakura Y.
Delineating metamorphic pathways in the ascidian Ciona intestinalis.
Dev Biol. (2009) 326:357-67.


Yasunori Sasakura, Aru Konno, Katsutoshi Mizuno, Nori Satoh, Kazuo Inaba
Enhancer detection in the ascidian Ciona intestinalis with transposase-expressing lines of Minos.
Developmental Dynamics (2008) 237: 39-50


Yasunori Sasakura, Yuichi Oogai, Terumi Matsuoka, Nori Satoh, Satoko Awazu
Transposon-mediated transgenesis in a marine invertebrate chordate, Ciona intestinalis.
Genome Biology (2007) 8: S3

Jean-Stephane Joly, Shungo Kano, Terumi Matsuoka, Helene Auger, Satoko Awazu, Laurent Legendre, Yasunori Sasakura.
Culture of Ciona intestinalis in closed systems
Developmental Dynamics (2007) 236: 1832-1840.

Yasunori Sasakura
Germline transgenesis and insertional mutagenesis in the ascidian Ciona intestinalis
Developmental Dynamics (2007) 236: 1758-1767.

Awazu Satoko, Terumi Matsuoka, Kazuo Inaba, Nori Satoh, Yasunori Sasakura
High Throughput enhancer trap by re-mobilization of transposon Minos in Ciona intestinalis.
Genesis (2007) 45: 307-317.


Yasunori Sasakura, Keisuke Nakashima, Satoko Awazu, Terumi Matsuoka, Akie Nakayama, Jun-ichi Azuma, Nori Satoh
Transposon-mediated insertional mutagenesis revealed the functions of animal cellulose synthase in the ascidian Ciona intestinalis.
Proceedings of National Academy of Science USA (2005) 102: 15134-15139.

Akie Nakayama, Nori Satoh, Yasunori Sasakura
Tissue-specific profile of DNA replication in the swimming larvae of Ciona intestinalis.
Zoological Science (2005) 22: 301-309.

Terumi Matsuoka, Satoko Awazu, Eiichi Shoguchi, Nori Satoh, Yasunori Sasakura
Germline transgenesis of the ascidian Ciona intestinalis by electroporation.
Genesis (2005) 41:61-72.


Satoko Awazu, Akane Sasaki, Terumi Matsuoka, Nori Satoh, Yasunori Sasakura
An enhancer trap in the ascidian Ciona intestinalis identifies enhancers of its Musashi orthologous gene.
Developmental Biology (2004) 275:459-472.

Terumi Matsuoka, Satoko Awazu, Nori Satoh, Yasunori Sasakura
Minos transposon causes germline transgenesis of the ascidian Ciona savignyi.
Development Growth & Differentiation (2004) 46: 249-255.


Yasunori Sasakura, Satoko Awazu, Shota Chiba, Nori Satoh
Germ-line transgenesis of the Tc1/mariner superfamily transposon Minos in Ciona intestinalis.
Proceedings of National Academy of Science U S A. (2003) 100:7726-7730.

Yasunori Sasakura, Satoko Awazu, Shota Chiba, Shungo Kano, Nori Satoh
Application of Minos, one of the Tc1/mariner superfamily transposable elements, to ascidian embryos as a tool for insertional mutagenesis.
Gene (2003) 308:11-20.